So the strongest neuroregenerative claims attributed to TB-500 are, strictly, claims about its parent protein component-level evidence, not direct evidence for the fragment
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CrossRef TRPC5 deletion in the central amygdala antagonizes high-fat diet-induced obesity by increasing sympathetic innervation Huan Ma, Chengkang He, Li Li, Peng Gao, Zongshi Lu, Yingru Hu, Lijuan Wang, Yu Zhao, Tingbing Cao, Yuanting Cui, Hongting Zheng, Gangyi Yang, Zhencheng Yan, Daoyan Liu, Zhiming Zhu International Journal of Obesity.2022
Gentle swirling rather than vortexing is recommended to avoid peptide denaturation from shear forces